Description / Anti-Human Cripto-1 monoclonal antibody
Cripto, also known as TDGF-1 (Teratocarcinoma-Derived Growth Factor), is the founding member of the Epidermal Growth Factor-Cripto-1/FRL1/Cryptic Protein family of signaling proteins that function in cancer and various developmental processes. Mouse Cripto shares 66% and 34% amino acid identity with human Cripto and zebrafish one-eyed pinhead (OEP), respectively. Genetic evidence from mice and zebrafish points to a role for Cripto as an essential cofactor in Nodal signaling.
More Information
| Size | 50 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#6M17) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant Cripto-1. |
| Antigen | human recombinant Cripto-1 |
| Application | WB |
| Synonyms | TDGF1; CR; CRGF; CRIPTO |
| Uniprot ID | P13385 |
| Protein RefSeq | NP_003203.1 |
| mRNA RefSeq | NM_003212.3 |