Description / anti-human CNTF R alpha monoclonal antibody
The high-affinity CNTF receptor complex, which mediates the biological action of CNTF, contains the ligand-binding alpha subunit (CNTF R alpha) and two signal-transducing proteins, LIF R beta and gp130. Whereas LIF R beta and gp130 are widely expressed in many cell types, the expression of CNTF R alpha is restricted to the central and peripheral nervous systems. cDNAs encoding CNTF R alpha isolated from both human and rat share 96% amino acid sequence identity.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#10L29) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CNTFRa. |
| Antigen | recombinant human CNTF R-alpha |
| Application | WB |
| Synonyms | CNTFR |
| Uniprot ID | P26992 |
| Protein RefSeq | NP_671693.1 |
| mRNA RefSeq | NM_147164.2 |