Description / human Chemerin protein
Chemerin is a secreted chemoattractant protein that can signal through the chemokine like receptor-1 (CMKLR1). It is expressed in various tissues, including white adipose tissue, and circulates in blood as an inactive 143 amino acid precursor protein. Biologically active Chemerin is generated by proteolytic removal of C-terminal residues by several circulating proteases. Chemerin acts as a chemoattractant for cells expressing the CMKLR1 receptor, which includes certain dendritic cells, macrophages, and adipocytes. Recombinant human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.
More Information
| Size | 250 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to chemoattract human immature dendritic cells using a concentration range of 1.0-100 ng/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 135 |
| Molecular Weight | 15.6 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFA |
| Synonyms | RARRES2; TIG2; HP10433 |
| Uniprot ID | Q99969 |
| Protein RefSeq | NP_002880.1 |
| mRNA RefSeq | NM_002889.3 |