Description / Chemerin
Chemerin is a secreted chemoattractant protein that can signal through the chemokine like receptor-1 (CMKLR1). It is expressed in various tissues, including white adipose tissue, and circulates in blood as an inactive 143 amino acid precursor protein. Biologically active Chemerin is generated by proteolytic removal of C-terminal residues by several circulating proteases. Chemerin acts as a chemoattractant for cells expressing the CMKLR1 receptor, which includes certain dendritic cells, macrophages, and adipocytes. Recombinant human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.
More Information
Size | 25 µg |
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Source | E. coli |
Biological Activity | Determined by its ability to chemoattract human immature dendritic cells using a concentration range of 1.0-100 ng/ml. |
Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
Length [aa] | 135 |
Molecular Weight | 15.6 kDa |
Species Reactivity | Human |
Formulation | lyophilized |
Protein Sequence | ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFA |
Synonyms | RARRES2; TIG2; HP10433 |
Uniprot ID | Q99969 |
Protein RefSeq | NP_002880.1 |
mRNA RefSeq | NM_002889.3 |