CDNF Human 25 µg

In stock

Cat-Nr.
100-400
Size
25 µg
  €221.00

Description / CDNF

CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.

More Information

Size 25 µg
Source E. coli
Biological Activity Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.
Purity Confirmation > 98% by SDS-PAGE & HPLC analyses
Length [aa] 162
Molecular Weight 18.5 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GAT kDaATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL
Synonyms cerebral dopamine neurotrophic factor, ARMETL1
Uniprot ID Q49AH0
Protein RefSeq NP_001025125
mRNA RefSeq NM_001029954

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