Description / CD28
CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Mouse CD28 is expressed constitutively on virtually 100% of mouse Tcells and on developing thymocytes.
More Information
Size | 100 µg |
---|---|
Source | Mouse |
Isotype | IgG1 |
Clone Nr. | (#12B3) |
Species Reactivity | Human |
Formulation | lyophilized |
Buffer | PBS |
Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CD28 extracellular domain. |
Antigen | Human recombinant CD28 EC domain |
Application | WB, FC, Stimulation |
Synonyms | CD28; Tp44 |
Uniprot ID | P10747 |
Protein RefSeq | NP_001230007.1 |
mRNA RefSeq | NM_001243078.1 |