Description / Anti-Human CD19 monoclonal antibody
B-lymphocyte antigen CD19 is a surface protein of the immunoglobulin superfamily. It binds to the B cell receptor on the cell surface of B cells and lowers the threshold of its activability. Thus, overexpression of CD19 in mice, as well as knockout mice, shows that CD19 affects the signaling threshold of receptors that regulate B lymphocyte selection, activation, and differentiation. At the molecular level, CD19 is involved in the activation of phosphatidylinositol 4,5-bisphosphate 3-kinases (PI3K). It is glycosylated and phosphorylated.
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| Size | 50 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#13Q82) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
| Antigen | Recombinant human CD19 |
| Application | FC |
| Synonyms | B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12 |
| Uniprot ID | P15391 |
| Protein RefSeq | NP_001171569.1 |
| mRNA RefSeq | NM_001178098.1 |