CCL-3 (MIP1 alpha) Anti-Human 100 µg

In stock

Cat-Nr.
101-M187
Size
100 µg
  €533.00

Description / CCL-3 (MIP1 alpha)

The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

More Information

Size 100 µg
Source Mouse
Isotype IgG2
Clone Nr. (#7D34)
Species Reactivity Human
Formulation lyophilized
Buffer PBS
Reconstitution Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CCL-3 (also called MIP-1a).
Antigen recombinant human CCL-3
Application Detection Ab
Synonyms CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
Uniprot ID P10147
Protein RefSeq NP_002974
mRNA RefSeq NM_002983

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