Description / anti-mouse Cathepsin E monoclonal antibody
Cathepsin E is an intracellular aspartic protease of the pepsin family. Unlike Cathepsin D, another member of the same family and a lysosomal protease with relatively ubiquitous distribution, Cathepsin E is not a lysosomal enzyme and has a limited cell and tissue distribution. However, both Cathepsins D and E play an important role in the degradation of proteins, the generation of bioactive proteins, and antigen processing. Both enzymes are efficient in cleaving the Swedish mutant of amyloid precursor protein (APP) at the β site but show almost no reactivity with the wildtype APP. Mouse Cathepsin E is synthesized as a precursor protein, consisting of a signal peptide (residues 1-18), a propeptide (residues 19-59), and a mature chain (residues 60-397).
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#7J15) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Cathepsin-E. |
| Antigen | recombinant mouse Cathepsin-E |
| Application | WB |
| Synonyms | Ctse; CE; CatE; A430072O03Rik; C920004C08Rik |
| Uniprot ID | P70269 |
| Protein RefSeq | NP_031825 |
| mRNA RefSeq | NM_007799 |