Cardiotrophin-1 Anti-Human 100 µg

In stock

Cat-Nr.
101-M242
Size
100 µg
  €533.00

Description / Cardiotrophin-1

Cardiotrophin1 (CT1) is a member of the cytokine family which also includes IL6, IL11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL6 family members on a variety of cell types. Human CT1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT 1 release from cells is currently not understood. Human and mouse CT1 share 80% aa sequence identity and exhibit crossspecies activity. CT1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT1 expression is also seen in testis and brain. CT 1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor β subunit. A third α receptor subunit has been implicated in the receptor complex.

More Information

Size 100 µg
Source Mouse
Isotype IgG1
Clone Nr. (#16T39)
Species Reactivity Human
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Cardiotrophin-1.
Antigen recombinant human Cardiotrophin-1
Application WB, IHC, Detection Ab
Synonyms CTF1; CT1; CT-1
Uniprot ID Q16619
Protein RefSeq NP_001321
mRNA RefSeq NM_001330

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