BMP-6 Human 10 µg

In stock

Cat-Nr.
100-378
Size
10 µg
  €221.00

Description / BMP-6

TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.

More Information

Size 10 µg
Source HEK 293 cells
Biological Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Purity Confirmation 95% by SDS-PAGE & HPLC analysis
Length [aa] 117
Molecular Weight 26.2 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
Synonyms BMP6; VGR; VGR1
Uniprot ID P22004
Protein RefSeq NP_001709
mRNA RefSeq NM_001718

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