BMP-4 (E. coli , Animal Free) Human 2 µg

In stock

Cat-Nr.
100-326S-AF
Size
2 µg
  €139.00

Description / BMP-4 (E. coli , Animal Free)

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.  The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa.

More Information

Size 2 µg
Source E. coli
Biological Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
Purity Confirmation ≥ 98% by SDS-PAGE gel and HPLC analyses
Length [aa] 106
Molecular Weight 23,9 kDa
Formulation lyophilized
Protein Sequence KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Synonyms BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS8
Uniprot ID P12644
Protein RefSeq NP_001193
mRNA RefSeq NM_001202
Pluripotent stem cells-derived organoids Blood vessel, Liver, Pancreas, Skin

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