Description / BMP-4 (E. coli , Animal Free)
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa.
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Size | 10 µg |
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Source | E. coli |
Biological Activity | Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml. |
Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses |
Length [aa] | 106 |
Molecular Weight | 23,9 kDa |
Formulation | lyophilized |
Protein Sequence | KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR |
Synonyms | BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS8 |
Uniprot ID | P12644 |
Protein RefSeq | NP_001193 |
mRNA RefSeq | NM_001202 |
Pluripotent stem cells-derived organoids | Blood vessel, Esophagus, Liver, Pancreas, Skin |