Description / human BMP-4 protein
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.
More Information
| Size | 10 µg |
|---|---|
| Source | CHO cells |
| Biological Activity | The ED50, as calculated by Alkaline phosphatase activity induced in ATDC-5 cells is 15ng/ml corresponding to a specific activity which is 6.7 x 10^4 units/mg. |
| Purity Confirmation | >95% by SDS-PAGE |
| Length [aa] | 116 |
| Molecular Weight | 26,2 kDa |
| Species Reactivity | Human, Mouse, Rat |
| Formulation | lyophilized |
| Buffer | 2XS PBS + 6% EtOH |
| Protein Sequence | SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR. |
| Synonyms | BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 |
| Uniprot ID | P12644 |
| Protein RefSeq | NP_001193 |
| mRNA RefSeq | NM_001202 |
| Pluripotent stem cells-derived organoids | Blood vessel, Esophagus, Liver, Pancreas, Skin |