BMP-4 Human 10 µg

In stock

Cat-Nr.
100-326
Size
10 µg
  €221.00

Description / BMP-4

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.

More Information

Size 10 µg
Source E. coli
Biological Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
Purity Confirmation >98% by SDS-PAGE and HPLC anaylsis
Length [aa] 106
Molecular Weight 23,9 kDa
Formulation lyophilized
Protein Sequence KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Synonyms BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS8
Uniprot ID P12644
Protein RefSeq NP_001193
mRNA RefSeq NM_001202
Pluripotent stem cells-derived organoids Blood vessel, Esophagus, Liver, Pancreas, Skin

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