Description / human BMP-13 (GDF6) protein
BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
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| Size | 500 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml. |
| Purity Confirmation | >95% by SDS-PAGE & HPLC analysis |
| Length [aa] | 120 |
| Molecular Weight | 27.0 kDa |
| Species Reactivity | Mouse, Human |
| Formulation | lyophilized |
| Protein Sequence | TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR |
| Synonyms | GDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MCOPCB6 |
| Uniprot ID | P43028 |
| Protein RefSeq | NP_038554.1 |
| mRNA RefSeq | NM_013526.1 |