BMP-10 Human 2 µg

In stock

Cat-Nr.
100-405S
Size
2 µg
  €112.00

Description / BMP-10

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.

More Information

Size 2 µg
Source HEK 293 cells
Biological Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.  The expected ED50 for this effect is 4.0-6.0 ng/ml.
Purity Confirmation >95% by SDS-PAGE & HPLC analysis
Length [aa] 108
Molecular Weight 24.4 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR
Synonyms BMP-10, Bone morphogenic protein 10
Uniprot ID O95393
Protein RefSeq NP_055297.1
mRNA RefSeq NM_014482.1

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