Description / human/murine/rat BDNF (Animal Free) protein
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
More Information
| Size | 100 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 119 |
| Molecular Weight | 27.0 kDa |
| Species Reactivity | Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human, Tadpole |
| Formulation | lyophilized |
| Protein Sequence | MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR |
| Synonyms | BDNF |
| Uniprot ID | P23560 |
| Protein RefSeq | NP_733931.1 |
| mRNA RefSeq | NM_170735.5 |
| Pluripotent stem cells-derived organoids | Cortical |