BDNF Human 10 µg

In stock

Cat-Nr.
100-005
Size
10 µg
  €221.00

Description / BDNF

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

More Information

Size 10 µg
Source E. coli
Biological Activity Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Purity Confirmation > 98% by SDS-PAGE & HPLC analyses
Length [aa] 119
Molecular Weight 27.0 kDa
Species Reactivity Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human, Tadpole
Formulation lyophilized
Protein Sequence MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Synonyms BDNF
Uniprot ID P23560
Protein RefSeq NP_733931.1
mRNA RefSeq NM_170735.5
Pluripotent stem cells-derived organoids Cortical

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