BD-5 (Animal Free) Human 5 µg

In stock

Cat-Nr.
100-038S-AF
Size
5 µg
  €139.00

Description / BD-5 (Animal Free)

Defensins (α and β) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.  To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.  β-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.  The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.  β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.  Recombinant Human BD-5 is a 5.8 kDa protein containing 51 amino acid residues.

More Information

Size 5 µg
Source E. coli
Biological Activity Not available.
Purity Confirmation ≥ 98% by SDS-PAGE gel and HPLC analyses.
Length [aa] 51
Molecular Weight 5,8 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence GLDFSQPFPS GEFAVCESCK LGRGKCRKEC LENEKPDGNC RLNFLCCRQR I
Synonyms BD5, DEFB5, DEFB105a, Beta-Defensin 5
Uniprot ID Q8NG35
Protein RefSeq NP_689463.1
mRNA RefSeq NM_152250.2

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