BD-4 Anti-Human 100 µg

In stock

Cat-Nr.
102-P221
Size
100 µg
  €271.00

Description / BD-4

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes.

More Information

Size 100 µg
Source Rabbit
Clone Nr. Rabbit IgG
Species Reactivity Human
Formulation lyophilized from PBS
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and Storage The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Preparation Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBD-4 (human Beta Defensin-4). Anti-Human BD-4 specific antibody was purified by affinity chromatography employing immobilized hBD-4 matrix.
Antigen E.coli derived Recombinant Human BD-4
Application ELISA, WB
Synonyms DEFB104A; BD-4; DEFB4; hBD-4; DEFB-4; DEFB104; DEFB104B
Uniprot ID Q8WTQ1
Protein RefSeq NP_525128.2
mRNA RefSeq NM_080389.2

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SKU: 100-331
€221.00

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