BD-1 (47aa) Human 5 µg

In stock

Cat-Nr.
100-133S
Size
5 µg
  €112.00

Description / BD-1 (47aa)

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.

More Information

Size 5 µg
Source E. coli
Biological Activity Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1000 ng/ml.
Purity Confirmation > 98% by SDS-PAGE & HPLC analyses
Length [aa] 47
Molecular Weight 5.0 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK
Synonyms DEFB1; BD1; HBD1; DEFB-1; DEFB101
Uniprot ID P60022
Protein RefSeq NP_5209.1
mRNA RefSeq NM_005218

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