human BAFF receptor, soluble protein Human 10 µg

B-cell-activating factor receptor (BAFF-R), also known as Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and CD268 antigen, is a member of the TNFR superfamily. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B) and initiates signalling pathways, which are critical for B cell maturation and survival. BAFF-R is highly expressed in spleen, lymph node, resting and activated B cells, resting CD4+ cells and peripheral blood leukocytes. Abnormally high levels of BAFF-R may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. Recombinant Human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.