Description / human BAFF receptor, soluble protein
BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.
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| Size | 250 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0 μg/ml of human soluble BAFF. |
| Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
| Length [aa] | 76 |
| Molecular Weight | 7.7 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG |
| Synonyms | TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin |
| Uniprot ID | Q96RJ3 |
| Protein RefSeq | NP_443177 |
| mRNA RefSeq | NM_052945 |