mouse BAFF Receptor (hFc-Tag) protein Mouse 100 µg
Description / mouse BAFF Receptor (hFc-Tag) protein
B-cell-activating factor receptor (BAFF-R), also known as Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and CD268 antigen, is a member of the TNFR superfamily. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B) and initiates signalling pathways, which are critical for B cell maturation and survival. BAFF-R is highly expressed in spleen, lymph node, resting and activated B cells, resting CD4+ cells and peripheral blood leukocytes. Abnormally high levels of BAFF-R may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. Recombinant Mouse BAFF Receptor (human Fc-Tag) is composed of the extracellular domain of mouse BAFF-R and a C-terminal human Fc-Tag. Recombinant Mouse BAFF Receptor (human Fc-Tag) has a molecular weight of approximately 40-45 kDa and consists of 303 amino acid residues.
More Information
| Size | 100 µg |
|---|---|
| Source | HEK 293 cells |
| Biological Activity | Immobilized human BAFF at 10 μg/mL (100 μL/well) binds mouse BAFF receptor (hFc-Tag). The EC50 for this effect is 0.14-0.32 μg/mL. |
| Purity Confirmation | > 90 % as determined by SDS-PAGE |
| Length [aa] | 303 |
| Molecular Weight | 40-45 kDa (Monomer) |
| Species Reactivity | Mouse, Human |
| Formulation | lyophilized |
| Buffer | PBS (pH 7.4), may vary depending on the Lot |
| Protein Sequence | A DNA sequence encoding the mouse BAFF Receptor (Q9D8D0-1) extracellular domain (Met 1-Ala 71) was fused with the Fc region of human IgG1 at the C-terminus. |
| Reconstitution | see Datasheet |
| Stability and Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Synonyms | B-cell-activating factor receptor, TNFRSF13C, Tumor necrosis factor receptor superfamily member 13C, BAFFR, CD268, CVID4, BAFF-R, BROMIX, prolixin, BLyS Receptor 3 |
| Uniprot ID | Q9D8D0-1 |
| Protein RefSeq | NP_082351.1 |
| mRNA RefSeq | NM_028075.3 |
| Endotoxin | < 0.1 ng/µg of protein (< 1 EU/µg) |