human BAFF protein Human 1000 µg
Description / human BAFF protein
BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant human soluble BAFF is a 153 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.
More Information
| Size | 1000 µg |
|---|---|
| Source | HEK 293 cells |
| Biological Activity | The biological activity of human BAFF is determined by binding human BAFF Receptor (Fc-Tag, AVI-Tag), Biotinylated in a functional ELISA. |
| Purity Confirmation | > 95 % as determined by SDS-PAGE |
| Endotoxin | < 0.1 ng/µg of protein (< 1 EU/µg) |
| Length [aa] | 389 |
| Molecular Weight | 48-55 kDa (Monomer) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | 0.5 x PBS pH 7.5 + 0.5 mM DTT |
| Protein Sequence | A DNA sequence encoding the soluble form of human BAFF (Q9Y275-1) (Ala 134-Leu 285) was fused with the Fc region of human IgG1 at the N-terminus. |
| Reconstitution | see Datasheet |
| Stability and Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Synonyms | TNFSF13B; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20 |
| Uniprot ID | Q9Y275 |
| Protein RefSeq | NP_006564.1 |
| mRNA RefSeq | NM_006573.4 |