APRIL Mouse 20 µg

In stock

Cat-Nr.
M10-050
Size
20 µg
  €221.00

Description / APRIL

APRIL (a proliferation inducing ligand), also known as TNFSF13, TALL2, and TRDL1, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa type II transmembrane protein which is cleaved by furin in the Golgi to release a 17 kDa soluble molecule. Secreted APRIL consists almost entirely of a single TNF homology domain. Little or no transmembrane APRIL is expressed on the cell surface. Alternate splicing generates isoforms with short deletions at the Nor C-terminus. Both APRIL and the closely related protein BAFF signal through the TNF superfamily receptors TACI and BCMA to promote cellular proliferation and protect from apoptosis. APRIL can form bioactive heterotrimers with BAFF. A bioactive cell surface-expressed protein known as TWEPRIL consists of the intracellular domain, transmembrane segment, and stalk region of TWEAK fused to the TNF homology domain of APRIL. Human APRIL shares 85% amino acid sequence identity with mouse and rat APRIL.

More Information

Size 20 µg
Source E. coli
Biological Activity Measured by its ability to induce cell proliferation of activated T cells.
Purity Confirmation > 98% by SDS-PAGE & HPLC analyses
Length [aa] 192
Molecular Weight 21.9 kDa
Species Reactivity Human, Mouse
Formulation lyophilized
Protein Sequence MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRRRAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL EAQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFRCIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SPHGTFLGFV KL
Synonyms Tnfsf13; April; Tall2; Trdl1; 2310026N09Rik
Uniprot ID Q9D777
Protein RefSeq NP_003799.1
mRNA RefSeq NM_023517.2

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