APRIL Human 10 µg

In stock

Cat-Nr.
100-379
Size
10 µg
  €221.00

Description / APRIL

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.

More Information

Size 10 µg
Source Insect cells
Biological Activity Tested by its ability to induce IgM secretion by CpG/CD40L treated human naive B cells, at a concentration of 500 ng/ml.
Purity Confirmation > 95% by SDS-PAGE & HPLC analyses
Length [aa] 146
Molecular Weight 16.3 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL
Synonyms TNFSF13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715
Uniprot ID O75888
Protein RefSeq NP_003799.1
mRNA RefSeq NM_003808.3

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