Amphiregulin (98aa) Human 50 µg

In stock

Cat-Nr.
100-393
Size
50 µg
  €204.00

Description / Amphiregulin (98aa)

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.

More Information

Size 50 µg
Source E. coli
Biological Activity Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.
Purity Confirmation > 97% by SDS-PAGE & HPLC analyses
Length [aa] 98
Molecular Weight 11.3 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence SVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSK
Synonyms AREG; AR; SDGF; AREGB; CRDGF
Uniprot ID P15514
Protein RefSeq NP_001648.1
mRNA RefSeq NM_001657.2

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