Description / Activin-A
Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.
More Information
| Size | 10 µg |
|---|---|
| Source | Insect cells |
| Biological Activity | The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. |
| Purity Confirmation | > 97% by SDS-PAGE & HPLC analyses |
| Length [aa] | 116 |
| Molecular Weight | 26.0 kDa |
| Species Reactivity | Chicken, Dog, Frog, Mouse, Rat, Human, Leech |
| Formulation | lyophilized |
| Buffer | 10 mM Sodium Citrate, pH 3.0 |
| Protein Sequence | GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS |
| Synonyms | INHBA; EDF; FRP |
| Uniprot ID | P08476 |
| Protein RefSeq | NP_002183.1 |
| mRNA RefSeq | NM_002192.2 |
| Adult stem cells-derived organoids | Lung |
| Pluripotent stem cells-derived organoids | Esophagus, Intestine, Liver, Lung, Pancreas, Stomach |