Description / Activin-A
Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.
More Information
Size | 10 µg |
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Source | CHO cells |
Biological Activity | Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. |
Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
Length [aa] | 116 |
Molecular Weight | 26.0 kDa |
Species Reactivity | Human, Mouse, Rat |
Formulation | lyophilized |
Protein Sequence | GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS |
Synonyms | Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein |
Uniprot ID | P08476 |
Protein RefSeq | NP_002183.1 |
mRNA RefSeq | NM_002192.2 |
Adult stem cells-derived organoids | Lung |
Pluripotent stem cells-derived organoids | Esophagus, Intestine, Liver, Lung, Pancreas, Stomach |