Mouse VCAM-1

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Cat-Nr.S01-M05S
Size10 µg
Price75 €
SourceCHO cells
Formulationlyophilized
Purity Confirmation≥ 98% by SDS-PAGE gel and HPLC analyses.
Molecular Weight87-97 dDa reducing conditions
Biological ActivityDetermined by its ability to support the adhesion of human U937 cells.
Species ReactivityHuman
SynonymsVascular Cell Adhesion Molecule 1; CD106; INCAM-100; MGC108734; MGC99561; VCAM; VCAM1; VCAM1B; VECAM1
DescriptionVCAM is a 110 kDa, cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development of several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant Murine VCAM-1 is a 74.4 kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of  VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 87-97 kDa by SDS-PAGE analysis under reducing conditions.
Protein SequenceFKIEISPEYK TIAQIGDSMA LTCSTTGCES PLFSWRTQID SPLNAKVRTE GSKSVLTMEP VSFENEHSYL CTATCGSGKL ERSIHVDIYS FPKDPEIQFS GPLEVGKPVT VKCLAPDIYP VYRLEIDLFK GDQLMNRQEF SSEEMTKSLE TKSLEVTFTP VIEDIGKALV CRAKLHIDQI DSTLKERETV KELQVYISPR NTTISVHPST RLQEGGAVTM TCSSEGLPAP EI
Uniprot IDP29533
Protein RefSeqNP_035823.3
mRNA RefSeqNM_011693.3

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