Human CD31/PECAM-1, soluble

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Cat-Nr.S01-071
Size50 µg
Price160 €
SourceInsect cells
LabelHis-Tag
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & Coomassie stain
Length [aa]582
Molecular Weight80-85 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Species ReactivityHuman
SynonymsPECAM-1; CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
DescriptionPECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions.
Protein SequenceQENSFTINSV DMKSLPDWTV QNGKNLTLQC FADVSTTSHV KPQHQMLFYK DDVLFYNISS MKSTESYFIP EVRIYDSGTY KCTVIVNNKE KTTAEYQVLV EGVPSPRVTL DKKEAIQGGI VRVNCSVPEE KAPIHFTIEK LELNEKMVKL KREKNSRDQN FVILEFPVEE QDRVLSFRCQ ARIISGIHMQ TSESTKSELV TVTESFSTPK FHISPTGMIM EGAQLHIKCT IQ
Uniprot IDP16284
Protein RefSeqNP_000433.4
mRNA RefSeqNM_000442.4

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