Mouse Persephin (PSP)

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Cat-Nr.M10-126S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 90% by SDS-PAGE & HPLC analyses
Length [aa]96
Molecular Weight10.3 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityThe ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg.
Species ReactivityHuman
SynonymsBpifa2; Psp; Bpifa2e
DescriptionPersephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. The GFRα4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Protein SequenceALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG
Uniprot IDO70300
Protein RefSeqNP_032980.2
mRNA RefSeqNM_008954

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