Mouse LIX/CXCL5 (70 aa)

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Cat-Nr.M10-030
Size20 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]70
Molecular Weight7.6 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.
Species ReactivityHuman, Mouse
SynonymsCxcl5; LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
DescriptionLIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant murine LIX is a 7.6 kDa protein consisting of amino acid residues 9-78 of the full length LIX protein (70 amino acids).
Protein SequenceTELRCVCLTV TPKINPKLIA NLEVIPAGPQ CPTVEVIAKL KNQKEVCLDP EAPVIKKIIQ KILGSDKKKA
Uniprot IDP50228
Protein RefSeqNP_033167.2
mRNA RefSeqNM_009141.2

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