Human BMP-2

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Size5 µg
Price90 €
SourceE. coli
Purity Confirmation> 95% by SDS-PAGE & visualized by silver stain
Length [aa]115
Molecular Weight26.0 kDa
N Terminal SequenceMQAKHKQ
Endotoxin Levels< 0.1 ng per µg of BMP-2
Biological ActivityMeasured by the ability of BMP-2 to induce alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 0.3-0.8 µg/ml.
Species ReactivityHuman
Buffer50 mM acetic acid
ReconstitutionThe lyophilized BMP-2 is best soluble in 50 mM acetic acid at a concentration of 0.1mg/ml but should be also soluble in most aqueous buffers when the pH is below 6.0.
Stability and StorageLyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted BMP-2 should be stored in working aliquots at -20 °C. Avoid repeated freeze-thaw cycles!
Synonymsbone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
DescriptionHuman Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. BMP-2 is a heparin binding protein.
Uniprot IDP12643
Protein RefSeqNP_001191
mRNA RefSeqNM_001200

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