Human HPRG

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Cat-Nr.100-439S
Size5 µg
Price75 €
SourceCHO cells
Formulationlyophilized
Purity Confirmation> 90% by SDS-PAGE & HPLC analyses
Length [aa]507
Molecular Weight57.7 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityMeasured by its ability to support adhesion of Con-A activated MOLT-4 cells to the Recombinant Human HPRG-coated surface. The ED50 for this effect is 1.5-2.0 μg/ml.
Species ReactivityHuman
SynonymsHistidine-Proline-Rich Glycoprotein, Histidine-rich glycoprotein (HRG), HRGP, THPH11
Description Histidine-proline-rich glycoprotein (HPRG), a member of the Cystatin structural superfamily, is an abundantly secreted multi-domain glycoprotein. Although the physiological function is largely unknown, HPRG potentially regulates physiological processes such as cell adhesion and migration, fibrinolysis, coagulation, complement activation, immune complex clearance and phagocytosis of apoptotic cells. HPRG can exert anti-angiogneic activity by stimulating apoptosis of endothelial cells. Recombinant Human HPRG is a 57.7 kDa glycoprotein containing 507 amino acid residues.
Protein SequenceVSPTDCSAVE PEAEKALDLI NKRRRDGYLF QLLRIADAHL DRVENTTVYY LVLDVQESDC SVLSRKYWND CEPPDSRRPS EIVIGQCKVI ATRHSHESQD LRVIDFNCTT SSVSSALANT KDSPVLIDFF EDTERYRKQA NKALEKYKEE NDDFASFRVD RIERVARVRG GEGTGYFVDF SVRNCPRHHF PRHPNVFGFC RADLFYDVEA LDLESPKNLV INCEVFDPQE HE
Uniprot IDP04196
Protein RefSeqNP_000403.1
mRNA RefSeqNM_000412.4

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