Human BMP-6

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Cat-Nr.100-378S
Size2 µg
Price75 €
SourceHEK293 cells
Formulationlyophilized
Purity Confirmation 95% by SDS-PAGE & HPLC analysis
Length [aa]117
Molecular Weight26.2 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Species ReactivityHuman
ReconstitutionCentrifuge the vial prior to opening!
SynonymsBMP6; VGR; VGR1
DescriptionTGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Protein SequenceVSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
Uniprot IDP22004
Protein RefSeqNP_001709
mRNA RefSeqNM_001718

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