Human FGF-21

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Cat-Nr.100-337
Size25 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 90% by SDS-PAGE & HPLC analyses
Length [aa]182
Molecular Weight19.5 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityFGF-21, in the absence of betaKlotho, shows weak activity of thymidine uptake by BaF3 cells expressing FGF receptors.
Species ReactivityHuman
SynonymsFGF21
DescriptionFGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes. Recombinant human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.
Protein SequenceMHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
Uniprot IDQ9NSA1
Protein RefSeqNP_061986.1
mRNA RefSeqNM_019113

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