Human IL-19

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Cat-Nr.100-229
Size10 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 99% by SDS-PAGE & HPLC analysis
Length [aa]153
Molecular Weight17.9 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to activate STAT following receptor-ligand interaction.
Species ReactivityHuman
SynonymsIL19; MDA1; NG.1; ZMDA1; IL-10C
DescriptionIL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-alpha and induces apoptosis through TNF-alpha. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.
Protein SequenceMLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA
Uniprot IDQ9UHD0
Protein RefSeqNP_715639.1
mRNA RefSeqNM_153758

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