Human Tissue factor (TF1)

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Cat-Nr.100-158S
Size2 µg
Price75 €
SourceCHO cells
LabelHis-Tag
Formulationlyophilized
Purity Confirmation> 95% by SDS-PAGE & HPLC analyses
Length [aa]214
Molecular Weight24.4 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityTesting in Progress.
Species ReactivityHuman
SynonymsTF, TF1, Coagulation factor III, factor III, F3, Thromboplastin, CD142
DescriptionTissue factor is a transmembrane glycoprotein of the cytokine receptor superfamily that acts as a receptor for coagulation factor VII (fVII) to trigger initiation of the coagulation cascade in response to vascular injury. Expression of tissue factor occurs constitutively within most extravascular and perivascular cells and at high levels within critical organs and tissue. Tissue factor is not normally expressed freely on the surface of circulating blood cells due to its pro-coagulant effect, but is instead stored on the surface of mononuclear and endothelial cells in micro particles that can shed into circulation in response to vascular injury, pro-inflammatory cytokines, or microbial ligands. Tissue factor can also be shed into circulation by cancer cells where its expression in a number of cancer types has been linked to tumor progression, metastatic potential, thrombosis, and angiogenesis. Expression of tissue factor has been shown to be inducible by select cytokines in a number of cell types, including IL-1 beta and TNF-alpha in vascular endothelial cells and macrophages, and TNF-alpha, IL-6, and FGF-Basic in monocytes, among others. Recombinant Human Tissue Factor is a glycoprotein homodimer comprised of the 214-amino-acid length monomer containing a C-terminal His-Tag. It has a calculated molecular weight of approximately 24.4 kDa, and as a result of glycosylation, Recombinant Human Tissue Factor migrates with an apparent molecular mass of approximately 45-55 kDa by SDS-PAGE gel, under reducing conditions.
Protein SequenceSGTTNTVAAY NLTWKSTNFK TILEWEPKPV NQVYTVQIST KSGDWKSKCF YTTDTECDLT DEIVKDVKQT YLARVFSYPA GNVESTGSAG EPLYENSPEF TPYLETNLGQ PTIQSFEQVG TKVNVTVEDE RTLVRRNNTF LSLRDVFGKD LIYTLYYWKS SSSGKKTAKT NTNEFLIDVD KGENYCFSVQ AVIPSRTVNR KSTDSPHHHH HHHH
Uniprot IDP13726
Protein RefSeqNP_001984.1
mRNA RefSeqNM_001993.4

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