Human MIP-1 alpha (CCL3)

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Cat-Nr.100-073S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analysis
Length [aa]69
Molecular Weight7.8 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityDetermined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.
Species ReactivityCow, Frog, Hamster, Monkey, Mouse, Rat, Human, Leech
ReconstitutionCentrifuge the vial prior to opening!
SynonymsCCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
DescriptionBoth MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant human MIP-1 alpha is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Protein SequenceASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Uniprot IDP10147
Protein RefSeqNP_002974.1
mRNA RefSeqNM_002983

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