Human IL-1 receptor antagonist (IRAP)
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Cat-Nr. | 100-043S |
Size | 20 µg |
Price | 95 € |
Source | E. coli |
Formulation | lyophilized |
Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
Length [aa] | 153 |
Molecular Weight | 17.2 kDa |
Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
Biological Activity | Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α. |
Species Reactivity | Frog, Mouse, Rat, Human |
Synonyms | IL1RN; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA |
Description | Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1 alpha and IL-1 beta by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues. |
Protein Sequence | MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE |
Uniprot ID | P18510 |
Protein RefSeq | NP_776214.1 |
mRNA RefSeq | NM_173842.2 |
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