Mouse BD-3

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Cat-Nr.M10-023
Size20 µg
Price170 €
CategoryCytokines & Growth Factors
SourceE. coli
Species ReactivityMouse
Formulationlyophilized
Purity Confirmation≥ 98% by SDS-PAGE gel and HPLC analyses
Length [aa]41
Molecular Weight4.6 kDa
SynonymsBeta-Defensin 3, DEFB3, DEFB103A
DescriptionDefensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-3 is a 4.6 kDa protein containing 41 amino acid residues.
Protein SequenceKKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKR K
Uniprot IDQ9WTL0
Protein RefSeqNP_038784.1
mRNA RefSeqNM_013756.2

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