Human Growth Hormone Receptor (hGH binding protein), soluble

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Size50 µg
Price350 €
CategorySoluble Receptors
SourceE. coli
Species ReactivityHuman
Purity Confirmation> 95.0% as determined by Gel filtration and SDS-PAGE gel.
Length [aa]247
Molecular Weight28.4 kDa
N Terminal SequenceAFSGS
ReconstitutionIt is recommended to reconstitute the lyophilized hGHBP in sterile 0.4% NaHCO3 adjusted to pH 8 or in distilled water, not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
SynonymsGH receptor, Somatotropin receptor, Growth hormone-binding protein (GH-binding protein; GHBP), Serum-binding protein
DescriptionThe somatotropin receptor (GHR) is the protein in the cell membrane of vertebrates to which the hormone somatropin (somatotropin, STH, GH), a growth factor, binds. The receptor belongs to the cytokine receptors. Its main actions are activation of a JAK-STAT signaling pathway, expression of insulin-like growth factor 1, and binding to the tyrosine kinase-coupled receptors SHP-2, which cause overall and length growth and fat loss in the body during the growth phase. Mutations in the GHR gene can lead to somatropin resistance and this can lead to a form of short stature called Laron syndrome. GHR in humans is produced primarily in liver and skeletal muscle. Three of the four GHR isoforms are transmembrane receptors, and the soluble isoform is called somatropin-binding protein (GHBP). It lacks the cytoplasmic domain, and by reversible binding to somatropin, it functions as a buffer for this hormone in blood plasma.
Uniprot IDP10912
Protein RefSeqNP_000154.1
mRNA RefSeqNM_000163.5

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