Rabbit Anti-Human TL-1A

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Cat-Nr.102-P253
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human TL-1A. Anti-Human TL-1A specific antibody was purified by affinity chromatography employing immobilized human TL-1A matrix.
Antigenrecombinant human TL-1A
ApplicationELISA, WB
SynonymsTNFSF15; TL1; TL1A; VEGI; VEGI192A
DescriptionTL1A is a type II transmembrane protein belonging to the TNF superfamily and has been designated TNF superfamily member 15 (TNFSF15). TL1A is predominantly expressed in endothelial cells and its expression is inducible by TNF-alpha and IL-1alpha. TL1A binds with high affinity to death receptor 3 (DR3), now known as TNFRSF25. Depending on the cell context, ligation of DR3 by TL1A can trigger one of two signaling pathways, activation of the transcription factor NF-kB, or activation of caspases and apoptosis.
Uniprot IDO95150
Protein RefSeqNP_005109
mRNA RefSeqNM_005118

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