Goat Anti-Human LD78-beta

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Cat-Nr.102-P169G
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Goat IgG
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of goats pre-immunized with highly pure (>98%) recombinant hLD78-Beta. Anti-hLD78-Beta specific antibody was purified by affinity chromatography employing immobilized hLD78-Beta matrix.
AntigenRecombinant human LD78-beta
ApplicationELISA, WB
SynonymsCCL3L1
DescriptionMIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils. The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.
Uniprot IDP16619
Protein RefSeqNP_066286.1
mRNA RefSeqNM_021006.4

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