Goat Anti-Human NP-1

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Cat-Nr.102-P194G
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Goat IgG
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of goats pre-immunized with highly pure (>98%) recombinant hNP-1. Anti-hNP-1 specific antibody was purified by affinity chromatography employing immobilized hNP-1 matrix.
ApplicationELISA, WB, N
SynonymsNeutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin
DescriptionDefensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins, which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
Uniprot IDP59665
Protein RefSeqNP_004075
mRNA RefSeqNM_004084

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