Rabbit Anti-Rat MIP-1 alpha

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Cat-Nr.104-P09
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityRat
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure recombinant Rat MIP1α. Anti-Rat MIP1α specific antibody was purified by affinity chromatography employing immobilized Rat MIP1α matrix.
AntigenRecombinant Rat MIP-1 alpha
ApplicationELISA, WB, N
SynonymsCcl3; Scya3; MIP-1a
DescriptionBoth MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and rat MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Uniprot IDP50229
Protein RefSeqNP_037157
mRNA RefSeqNM_013025

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