Rabbit Anti-Human IL-33

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Cat-Nr.102-P238
Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman
Formulationlyophilized from PBS
BufferPBS
ReconstitutionReconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
Stability and StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human IL-33. Anti-Human IL-33 specific antibody was purified by affinity chromatography employing immobilized human IL-33 matrix.
AntigenRecombinant human IL-33
ApplicationELISA, WB
SynonymsIL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2
DescriptionIL-33 is a proinflammatory protein that may also regulate gene transcription. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines and is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1alpha or IL-1 beta stimulation. Similar to IL-1, IL-33 can be cleaved in vitro by caspase-1, generating an N-terminal fragment that is slightly shorter than the C-terminal fragment. The N-terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain.
Uniprot IDO95760
Protein RefSeqNP_254274
mRNA RefSeqNM_033439

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